Quinolines and derivatives

Apexbio Technology LLC GSK1070916 942918-07-2 200mg

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GSK1070916 (CAS 942918-07-2) is a selective ATP-competitive inhibitor targeting Aurora kinase B and C displaying Ki values of 0 38 nM and 1 5 nM respectively The compound demonstrates marked selectivity over Aurora kinase A with IC50 values of approximately 5 nM (Aurora B) versus 1259 nM (Aurora A) In vitro studies show that GSK1070916 inhibits proliferation of human lung cancer cells (A549) with an EC50 of roughly 7 nM Additionally the compound effectively reduces phosphorylation of histone H3 an Aurora B substrate and exhibits tumor growth inhibition in HL-60 xenograft mouse models GSK1070916 is utilized in tumor biology research investigating Aurora kinase signaling pathways

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Apexbio Technology LLC Elesclomol (STA-4783) 488832-69-5 200mg

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Elesclomol (STA-4783 CAS 488832-69-5) is a small molecule identified through phenotype-based screens for apoptotic activity which induces apoptosis in cancer cells by elevating intracellular reactive oxygen species (ROS) Its primary cellular target is mitochondrial electron transport disruption of which results in rapid accumulation of oxidative stress exceeding adaptive thresholds and ultimately triggering apoptotic cell death Elesclomol demonstrates antitumor activity across diverse human tumor xenograft models and is currently studied as an investigational anticancer compound capable of extending progression-free survival

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Apexbio Technology LLC GDC-0941 957054-30-7 200mg

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GDC-0941 (CAS 957054-30-7) is a selective small-molecule inhibitor of class I phosphoinositide 3-kinase (PI3K) a critical component involved in the PI3K/Akt signaling pathway frequently dysregulated in cancer By competitively binding to the ATP-binding site of PI3K GDC-0941 inhibits generation of the downstream signaling molecule phosphatidylinositol-3 4 5-trisphosphate (PIP3) Exhibiting high selectivity against p110 / (IC50 approx 3 nM) and moderate selectivity for p110 (33 nM) and p110 (75 nM) GDC-0941 has demonstrated antiproliferative activity across diverse tumor cell lines in vitro (e g A2780 PC3 U87MG) and tumor growth inhibition in xenograft cancer models supporting its utility in cancer research

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Medchemexpress LLC MEDCHEMEXPRESS LLC

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5000772543 MAL-C6-AMINE TFA 10G

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Apexbio Technology LLC Ki16198 355025-13-7 200mg

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Ki16198 (CAS 355025-13-7) is the methyl ester derivative of Ki16425 and functions as an antagonist of lysophosphatidic acid (LPA) receptors preferentially inhibiting LPA1 and LPA3 receptor subtypes Ki16198 reduces receptor-mediated inositol phosphate production with Ki values of 0 34 M (LPA1) and 0 93 M (LPA3) showing minimal inhibition of LPA2 and no significant activity against LPA4 6 In vitro Ki16198 attenuates LPA-induced proliferation migration invasion and proMMP-9 expression in cancer cells In vivo studies report suppression of pancreatic tumor growth metastasis and ascites formation highlighting its utility in investigating LPA-related cancer progression pathways

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Apexbio Technology LLC MK-5108 (VX-689) 1010085-13-8 200mg

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MK-5108 (VX-689 CAS 1010085-13-8) is a selective inhibitor targeting Aurora A kinase (AAK) functioning through competitive interaction with its ATP-binding pocket It exhibits sub-nanomolar inhibition of Aurora A kinase (IC50 0 064 nM) and displays additional inhibitory activity against Aurora B and Aurora C kinases (IC50 14 nM and IC50 12 nM respectively) MK-5108 has been extensively studied in cancer research contexts demonstrating antiproliferative activity across various tumor types including breast cervical colorectal ovarian and pancreatic cancers

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Apexbio Technology LLC Cobicistat (GS-9350) 1004316-88-4 200mg

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Cobicistat (GS-9350) is a selective inhibitor of cytochrome P450 3A enzyme (CYP3A) showing inhibitory activity with an IC50 ranging from 0 03 to 0 285 M in vitro It lacks intrinsic anti-HIV activity but serves primarily as a pharmacokinetic enhancer used in combination therapy to increase the systemic exposure of HIV-1 protease inhibitors such as atazanavir and darunavir Clinically cobicistat is administered orally to HIV-1-infected adults facilitating optimized dosing regimens Due to its selective CYP3A inhibitory mechanism cobicistat is employed in pharmacokinetic studies and drug-drug interaction investigations related to HIV treatments

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8-Hydroxyquinoline (White to Light-Buff Needles or Powder), Fisher BioReagents

CAS: 148-24-3 Molecular Formula: C9H7NO Molecular Weight (g/mol): 145.16 MDL Number: MFCD00006807 InChI Key: MCJGNVYPOGVAJF-UHFFFAOYSA-N Synonym: 8-hydroxyquinoline,8-quinolinol,oxyquinoline,oxine,quinophenol,8-quinol,8-oxyquinoline,phenopyridine,oxychinolin,bioquin PubChem CID: 1923 ChEBI: CHEBI:48981 IUPAC Name: quinolin-8-ol SMILES: OC1=C2N=CC=CC2=CC=C1

Ethidium Bromide, Fisher BioReagents

CAS: 1239-45-8 Molecular Formula: C21H20BrN3 Molecular Weight (g/mol): 394.32 MDL Number: MFCD00011724 InChI Key: ZMMJGEGLRURXTF-UHFFFAOYSA-N Synonym: ethidium bromide,homidium bromide,dromilac,3,8-diamino-5-ethyl-6-phenylphenanthridinium bromide,ethydium bromide,3,8-diamino-5-ethyl-6-phenylphenanthridin-5-ium bromide,etbr,2,7-diamino-10-ethyl-9-phenylphenanthridinium bromide,2,7-diamino-9-phenyl-10-ethylphenanthridinium bromide,unii-059nuo2z1l PubChem CID: 14710 ChEBI: CHEBI:4883 IUPAC Name: 5-ethyl-6-phenylphenanthridin-5-ium-3,8-diamine;bromide SMILES: [Br-].CC[N+]1=C(C2=CC=CC=C2)C2=CC(N)=CC=C2C2=CC=C(N)C=C12

2-Hydroxyquinoline-4-carboxylic acid, 98%, Thermo Scientific™

CAS: 15733-89-8 Molecular Formula: C10H7NO3 Molecular Weight (g/mol): 189.17 MDL Number: MFCD00023942 MFCD00464512 InChI Key: MFSHNFBQNVGXJX-UHFFFAOYSA-N Synonym: 2-hydroxyquinoline-4-carboxylic acid,2-oxo-1,2-dihydroquinoline-4-carboxylic acid,2-hydroxy-4-quinolincarboxylic acid,2-hydroxycinchoninic acid,cinchoninic acid, 2-hydroxy,4-carboxycarbostyril,2-oxocinchoninic acid,4-quinolinecarboxylic acid, 1,2-dihydro-2-oxo,2-hydroxy-quinoline-4-carboxylic acid,2-hydroxy-4-quinolinecarboxylic acid PubChem CID: 85076 ChEBI: CHEBI:52045 IUPAC Name: 2-oxo-1H-quinoline-4-carboxylic acid SMILES: OC(=O)C1=CC(=O)NC2=CC=CC=C12

Thermo Scientific Chemicals 5-Chloro-8-hydroxy-7-iodoquinoline, 98%, Thermo Scientific™

9-Acridinecarboxaldehyde, 97%, Thermo Scientific Chemicals

CAS: 885-23-4 Molecular Formula: C₁₄H₉NO Molecular Weight (g/mol): 207.23 InChI Key: ISOCABSXIKQOOV-UHFFFAOYSA-N Synonym: 9-formylacridine,9-acridinecarboxaldehyde,9-acridinealdehyde,acridine, 9-formyl,acridine-9-carboxaldehyde,9-acridinecarboxaldehyde 8ci 9ci,9-acridine carboxaldehyde,9-acridinecarbaldehyde PubChem CID: 98663 IUPAC Name: acridine-9-carbaldehyde SMILES: C1=CC=C2C(=C1)C(=C3C=CC=CC3=N2)C=O

Ethidium Bromide, DNase, RNase and Protease Free 99+%, Thermo Scientific™

CAS: 1239-45-8 Molecular Formula: C21H20BrN3 Molecular Weight (g/mol): 394.32 MDL Number: MFCD00011724 InChI Key: ZMMJGEGLRURXTF-UHFFFAOYSA-N Synonym: ethidium bromide,homidium bromide,dromilac,3,8-diamino-5-ethyl-6-phenylphenanthridinium bromide,ethydium bromide,3,8-diamino-5-ethyl-6-phenylphenanthridin-5-ium bromide,etbr,2,7-diamino-10-ethyl-9-phenylphenanthridinium bromide,2,7-diamino-9-phenyl-10-ethylphenanthridinium bromide,unii-059nuo2z1l PubChem CID: 14710 ChEBI: CHEBI:4883 IUPAC Name: 3,8-diamino-5-ethyl-6-phenylphenanthridin-5-ium bromide SMILES: [Br-].CC[N+]1=C(C2=CC=CC=C2)C2=CC(N)=CC=C2C2=CC=C(N)C=C12

Thermo Scientific Chemicals Sildenafil

CAS: 139755-83-2 Molecular Formula: C22H30N6O4S Molecular Weight (g/mol): 474.58 InChI Key: BNRNXUUZRGQAQC-UHFFFAOYSA-N IUPAC Name: 5-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1H,4H,7H-pyrazolo[4,3-d]pyrimidin-7-one SMILES: CCCC1=NN(C)C2=C1NC(=NC2=O)C1=CC(=CC=C1OCC)S(=O)(=O)N1CCN(C)CC1

Thermo Scientific Chemicals 2-Phenyl-4-quinolinecarboxylic acid, 99%, Thermo Scientific™